Projects
Etude épidémiologique de la leishmaniose canine à 'Leishmania infantum' et son impact sur la leishmaniose viscérale humaine sur le littoral algérien Institute of Tropical Medicine
Unravelling the cellular and molecular mechanisms underlying B-cell dysfunction during Leishmania donovani infections. Vrije Universiteit Brussel
Scrutinizing the role of mast cells during human and murine Leishmania infections KU Leuven
Despite a global distribution of Leishmaniasis and 1.5 to 2 million new cases annually, no effective human vaccines are available and treatment failure with current drugs is on the rise. Mast cells (MCs) are immune sentinels in the skin that are amongst the first to contact the Leishmania parasite following a sand fly bite. These cells play major roles in orchestrating early inflammatory responses, regulating vascular permeability and ...
Scrutinizing the role of mast cells during human and murine Leishmania infections. University of Antwerp
Cellular, molecular and functional characterization of quiescence in Leishmania donovani, the etiological agent of visceral leishmaniasis Institute of Tropical Medicine
Cellular, molecular and functional characterization of quiescence in Leishmania donovani, the etiological agent of visceral leishmaniasis Institute of Tropical Medicine
Elucidating the role of alternative trans-splicing in the mRNA abundance regulation of Leishmania. University of Antwerp
Induction of miltefosine (MIL)-resistance on Leishmania amastigotes: study of the effect of resistance on MIL-internalisation, processing and parasitic fitness. University of Antwerp
Revealing the molecular mechanisms and adaptive role of aneuploidy plasticity in Leishmania spp Institute of Tropical Medicine
Most eukaryotes have evolved to maintain strict control over the structural transmission of their genomes across several generations. However, in Leishmania, this is not the case. These protozoan parasites have a highly plastic genome characterized by rapid modulation of chromosome copy number, leading to the co-existence of cells with diverging aneuploid karyotypes even in clonal populations. Such modulations in aneuploidy are reflected on ...