Projects
Characterisation of the human gut virome in patients with liver steatosis in order to identify biomarkers for diagnosis and targets for drug development. KU Leuven
Changes in the gut bacterial composition have been seen in patients with chronic liver diseases and their gut barrier is impaired, resulting in an increased presence of microbial products in the portal vein. This vein transports the products to the liver, where they activate the immune system and thereby contribute to inflammation and fibrogenesis. Bacteria are also involved in the progression from decompensation towards acute-on-chronic ...
Role of angiogenesis and angiogenetic factors (VEGF, PLGF) in portal hypertension and fibrosis formation in animal models of cirrhosis, steatosis and portal hypertension Vrije Universiteit Brussel
VUB - Human stem cells-on-a-chip: a new 3D platform for research in steatosis induced by drugs. Ghent University
Development of a human skin stem cell-derived in vitro model for the investigation of drug-induced steatosis and its mode of action. Vrije Universiteit Brussel
Uncovering liver macrophage subsets and the role of macrophage prolyl hydroxylases in the pathogenesis of non-alcoholic steatohepatitis and associated liver cancer Ghent University
Non-alcoholic fatty liver disease is an important cause of chronic liver disease in Western countries. The disease ranges from simple steatosis (lipid accumulation) to non-alcoholic steatohepatitis (NASH) (liver inflammation related to steatosis) which can result in liver cirrhosis and even in NASH-induced hepatocellular carcinoma (NASH-HCC). Macrophages (Mf) are innate immune cells with diverse functions related to their origin and local ...
The adipose tissue and liver in human non-alcoholic fatty liver disease: Characterization on a single-cell level KU Leuven
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, that encompasses a disease spectrum ranging from simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, to the development of hepatocellular carcinoma (HCC). Patients with simple steatosis (an accumulation of lipids in hepatocytes) are largely asymptomatic and only a fraction of patients will develop the more severe NASH, or NASH with ...