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Protocol, rationale and design of BE-PEOPLE (Bedaquiline enhanced exposure prophylaxis for LEprosy in the Comoros): a cluster randomized trial on effectiveness of rifampicin and bedaquiline as post-exposure prophylaxis of leprosy contacts Institute of Tropical Medicine

Assoumani Younoussa, Said Nourdine Samidine, Auke T Bergeman, Alberto Piubello, Nissad Attoumani, Silahi Halifa Grillone, Sofie Braet, Achilleas Tsoumanis, Abdallah Baco, Aboubacar Mzembaba, et al.

BACKGROUND: Leprosy is an ancient infectious disease with an annual global incidence of around 200,000 over the past decade. Since 2018, the World Health Organization (WHO) recommends single-dose rifampicin as post-exposure prophylaxis (SDR-PEP) for contacts of leprosy patients. The Post ExpOsure Prophylaxis for Leprosy (PEOPLE) trial evaluated PEP with a double dose of rifampicin in Comoros and Madagascar. Preliminary results of this trial ...

Recent advances in leprosy and Buruli ulcer (Mycobacterium ulcerans infection) Institute of Tropical Medicine

DS Walsh, Françoise Portaels, WM Meyers
PURPOSE OF REVIEW: After tuberculosis, leprosy (Mycobacterium leprae) and Buruli ulcer (M. ulcerans infection) are the second and third most common mycobacterial infections in humankind, respectively. Recent advances in both diseases are summarized. RECENT FINDINGS: Leprosy remains a public health problem in some countries, and new case detections indicate active transmission. Newly identified M. lepromatosis, closely related to M. leprae, may ...

Investigating drug resistance of Mycobacterium leprae in the Comoros University of Antwerp Institute of Tropical Medicine

Sofie Braet, Agathe Jouet, Alexandra Aubry, Magalie Van Dyck-Lippens, Esteban Lenoir, Younoussa Assoumani, Abdallah Baco, Aboubacar Mzembaba, Emmanuelle Cambau, Sidra Ezidio Goncalves Vasconcellos, et al.
Background Despite strong leprosy control measures, including effective treatment, leprosy persists in the Comoros. As of May, 2022, no resistance to anti-leprosy drugs had been reported, but there are no nationally representative data. Post-exposure prophylaxis (PEP) with rifampicin is offered to contacts of patients with leprosy. We aimed to conduct a countrywide drug resistance survey and investigate whether PEP led to the emergence of drug ...

Armand Van Deun - pioneering public health physician (1953-2023) Institute of Tropical Medicine

H L Rieder, E Declercq, Leen Rigouts, A Piubello, N E Billo, Fatoumata Ba, A Trebucq, C.Y. Chiang, Françoise Portaels
Armand Van Deun was born on 2 November 1953 in Brecht, Belgium. He obtained his medical degree in 1978 from one of Europe’s oldest universities, the Katholieke Universiteit Leuven, Belgium. After preparing himself for clinical work in Africa, he took a post as Regional Tuberculosis and Leprosy Coordinator in the Kigoma region of Tanzania from 1979 to 1985. Being among the first in the world, he applied the highly efficacious and effective ...

The reduction of the leprosy endemicity in northeastern Zaire 1975/1989 Institute of Tropical Medicine

R Tonglet, STEFAAN PATTYN, NN Bola, E Eeckhout, J Deverchin
The leprosy endemy in Uele, North Eastern region of Zaire has declined considerably since the 1950's, particularly since 1975. The hypothesis is advanced that the most important causal factor has been the distribution of dapsone for many years, through a vertical programme. The gradual increase of dapsone resistance has been taken care of by the introduction of combined, multidrug therapy in the 1980's. The cost per patient detected and treated ...