Regulation of lysosomal function by ryanodine receptormediated Ca2+ release in health and disease KU Leuven
Disruption of lysosomal function is an early event in the development of Alzheimer’s disease (AD). The origin of this lysosomal dysfunction is still extensively studied and may be directly related to intracellular accumulation of AD associated amyloid beta in the lysosomes impairing their function. Another early event in AD is the dysregulation of intracellular Ca2+ release which impacts among other processes memory formation. Excessive ...