Projects
Disease resolution mechanisms and interrelation with dysmetabolism in severe malaria KU Leuven
Malaria is a worldwide health problem with a high disease burden. More than 200 million clinical cases and 600000 deaths occur each year. Most of the lethality is due to malaria complications, such as cerebral malaria and malaria-associated acute respiratory distress syndrome. Metabolic disturbances are also highly associated with mortality. Current antimalarial treatment is based on highly efficient artemisinin combination therapies which ...
The interrelation between endogenous glucocorticoids, inflammation and metabolic disturbances in malaria KU Leuven
Yearly, almost half a million of people die from malaria, a global parasitic disease. The mechanisms that explain why some people progress from uncomplicated to complicated malaria remain poorly characterized and this impedes the development of novel treatments. Disease tolerance mechanisms promote survival by limiting the pathological consequences of the infection without interfering with parasite load. In our recent study, we revealed that ...
Targeting malaria transmission: a transdisciplinary approach Institute of Tropical Medicine
Understanding social vulnerability for malaria control and elimination Institute of Tropical Medicine
Strengthening national efforts to eliminate malaria in Peru (CeroMalariaPeru) University of Antwerp
Residual malaria transmission and additional control measures to long-lasting insecticidal nets in Cambodia: an anthropological study Institute of Tropical Medicine
Modelling transmission dynamics for malaria control and elimination in Peru Institute of Tropical Medicine
Inflammation and dysmetabolism in malaria KU Leuven
With > 200 million clinical cases and over 400 thousands deaths each year, malaria remains a major health problem. In our research group, we focus on malaria complications, which are the main cause of death in malaria patients and arise from complex interactions between the parasite and the host immune and vascular systems. We investigate the pathogenesis of these complications and aim to develop improved therapies. Advanced mouse models, ...