Projects
Can sleep disturbances lead to functional connectivity changes in mice brain? University of Antwerp
Diabetes reversal in NOD mice by L.lactis-based Ag therapy in combination with low dose anti-CD3. KU Leuven
Research to understand the mechanism of action and the nature of the regulatory T cells induced by therapy by the diabetes reversal in NOD mice by L.lactis-based Ag therapy in combination with low dose anti-CD3.
High-frequency ultrasound device for the non-invasive study of cardiac and arterial function in mice with genetically determined cardiovascular disorders Ghent University
The requested device is advanced ultrasound equipment which allows to sequentially study, in a non-invasive way and with great precision, the cardiac and arterial function in mice. The equipment with in particular be used in our research on the origin and progression of aortic pathologies (aortic aneurysms and disections) in mouse models of genetically determined cardiovascular pathologies
Study of the earliest extracellular and intracellular interactions of the hepatitis C virus with human hepatocytes in chimeric uPA-SCID mice Ghent University
uPA-SCID mice can be infected with the hepatitis C virus (HCV) after they have been transplanted with human hepatocytes. In this research project we will evaluate in vivo the different steps in viral entry and evaluate different approaches to prevent HCV infection. In addition, we will map all changes in gene and protein expression that occur in the human hepatocytes that occur early after HCV entry. This may provide insight in the mechanism ...
Study of hepatitis E virus infections in cell culture and in mice with humanized liver. Ghent University
In this project we want to establish a cell culture and a small annimal model for the study of the hepatitis E virus (HEV. We will investigate the interactions between the virus and the host and will evaluate novel antiviral therapies against this pathogen.
Impact on angiogenesis and ER stress and its effect on chemoresistance through P1GF inhibition in a mice model of hepatocellular carcinoma. Ghent University
Hepatocellular carcinoma is third cause of cancer-related mortality. Cytostatics provide no improved survival. Chemoresistance modification is needed. Hypoxia and endoplasmic reticulum stress can cause chemoresistance. The efficacy of anti-P1GF suggests that this may be a future antineoplastic. Farnesylthiosalicylic acid is RAS competitor. HCC mouse model is used to evaluate anti-P1GF and farnesylthiosalicylic acid on hypoxia, ER stress and ...