Projects
Identificatie van kleine moleculaire ErbB4 agonisten ter behandeling van cardiovasculaire ziekten. University of Antwerp
Molecular determinants of Bcl–2 and Bcl–Xl binding to the IP3R channel and regulation of its activity at the molecular and functional level in normal and apoptotic cells KU Leuven
B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-Xl) are major anti-apoptotic proteins, members of the Bcl-2 family, which have a key role in the regulation of cell-fate decisions. Bcl-2 and Bcl-Xl share all four B-cell homology (BH1-4) domains, with an N-terminal BH4 domain and a hydrophobic cleft formed by the BH3-BH2-BH1 domains. Bcl-2 and Bcl-Xl also possess a C-terminal trans-membrane domain (TMD), which is responsible for ...
Towards molecular control of electrophilic aromatic substitution reactions in homogeneous and heterogeneous environments through a combined ab initio molecular dynamics and conceptual density functional theory approach. Ghent University
The electrophilic aromatic substitution (SEAr) is a cornerstone reaction discovered by Friedel and
Crafts in the 19th century. Despite its industrial importance for ethylbenzene production, the
reaction mechanism is still debated. The proposed mechanistic pathway, relying on the formation of
arenium ion intermediates, was recently challenged on experimental and theoretical grounds. The
formation of the commonly assumed ...
Towards molecular control of electrophilic aromatic substitution reactions in homogeneous and heterogeneous environments through a combined ab initio molecular dynamics and conceptual density functional theory approach. Vrije Universiteit Brussel
Characterizing genes and molecular mechanisms involved in frontotemporal lobar degeneration (FTLD) using an integrated approach of molecular genetics and functional genomics. University of Antwerp
Integrated molecular profiling in neuroblastoma: identification of new molecular therapeutic targets and optimalised prognostic classification Ghent University
The aim of this project is to identify genes and signalling pathways through improved data mining as a result from combined genomic screening strategies. This information will lead to development of molecular oriented therapies. Also, extensive mRNA and miRNA profiling will be conducted in order to establish robust prognostic signature which will be applied for improved theratpeutic stratification.
The bread improving mechanism of molecular oxygen and potassium bromate: unraveling the mystery on molecular scale. KU Leuven
Danger-associated molecular patters: revealing the molecular signals dictating the communication between dying cells with the immune system Ghent University
Defective interactions of dying cells with the innate and adaptive immune system contribute to the development of cancer and autoimmunity. The main goal of current project is to study the mechanisms behind immunogenicity of cell death pathways induced by various cytotoxic agents (including ROS-based strategies such as PDT) and to further strengthen the “anticancer vaccine effect” concept.