Projects
The Role of Parkinsonism genes in synaptic autophagy Vrije Universiteit Brussel
occurrence of typical motor symptoms and is commonly associated with the aggregation of the
protein alpha-synuclein. While idiopathic cases are often associated with numerous risk factors,
familial cases are caused by mutations in >22 different genes. Many of these genes point to a variety
of underlying molecular ...
Evolution at the plant apex: identifying steps enabling a major organismal radiation Flanders Institute for Biotechnology
Capturing the ubiquitination and protein interaction landscape of the central regulator of nodulation TOO MUCH LOVE in soybean Ghent University
Soybean is one of the most important plant-based protein sources for food and feed. This legume acts as a natural nitrogen fertilizer by establishing a symbiotic relationship with nitrogen-fixing rhizobia in a process called nodulation. As nodulation is energetically costly, the number of formed nodules is tightly regulated through a systemic pathway called autoregulation of nodulation (AON). The key component acting at the final stages of ...
Cell cycle reprogramming during xylem development Ghent University
Plant xylem tissues serve an important dual role during growth and development of plants as they are required for both physical support and water transport. Moreover, modulation of xylem characteristics like size and number of xylem vessels provides a vital mechanism to cope with environmental stress. Hence, a comprehensive understanding of the regulatory network of xylem development can greatly benefit plant health and crop yield. Although ...
Identifying novel regulators of the ChREBP-MLX complex KU Leuven
The ability to adapt metabolism in response to fluctuating nutrients is critical to maintain energy homeostasis. In a nutrient-rich condition, an organism stores the surplus of energy as energy-dense molecules (e.g., lipids) which are leveraged to maintain the basal activity upon fasting. In vertebrates, adipose tissue and the liver are the two main organs that convert excess carbohydrates (e.g., glucose) to lipids, a process defined as de ...
Developmental mechanisms of diversification of visual areas in the mouse cerebral neocortex KU Leuven
The higher-order (HO) cortex substantiates higher-order brain functions and is evolutionarily elaborated in humans, with expanded territory and subdivisions (areas) that are devoted to distinct neural computations and functions. However little is known about how HO cortical areas emerge during cortical development. Recent studies in neonatal mice suggested parallel HO thalamocortical pathways from the lateral posterior nucleus (LP) drive the ...
Structural variants impacting peripheral neurodegeneration. Flanders Institute for Biotechnology
Investigation of NGS-intractable mutational classes in peripheral neurodegeneration. Flanders Institute for Biotechnology
COSMMOS: Characterising and Optimising the production flux of Secondary Metabolites in Clostridia using a hybrid Mechanistic machine learning multi-OmicS pipeline KU Leuven
The aim of this project is to predict the production flux of heterologously synthesised bioactive natural products in Clostridium strains using a supervised multi-omics inference pipeline harnessing both mechanistic and machine learning concepts.
Natural products (NPs) are compounds synthesised through a non-growth-associated metabolic process encoded within a biosynthetic gene cluster (BGC). NP families like polyketides and ...