Projects
Single cell analysis of inflammasome-mediated IL-1ß secretion in primary human monocytes Ghent University
Dysregulated IL-1β signaling is implicated in the pathogenesis of auto-inflammatory and autoimmune disorders. However, how human monocytes – the main source of IL-1β in patients - activate the NLRP3 inflammasome and release IL-1β remains ambiguous. The ‘alternative’ NLRP3 inflammasome pathway has recently been proposed as an active secretion pathway of IL-1β primarily based on studies in the immortalized BLaER1 cell line. In this pathway, the ...
The role of microRNAs in the regulation of inflammation and oxidative stress in monocytes during obesity and associated metabolic disorders. KU Leuven
Epstein Barr-virus and multiple sclerosis: new tricks from an old dog. Does imprinting of inflammatory monocytes provide an answer? Hasselt University
Peripheral blood monoicytes as potential predictive biomarkers for colorectal cancer diagnosis and progression. KU Leuven
Deciphering the molecular pathways needed to restore monocyte dysfunction during Acute-on-chronic liver failure KU Leuven
Acute-on-chronic liver failure (ACLF): monocyte profiles as a predictor for progression or recovery signatures in patients. KU Leuven
We aim to study the dynamics of the monocyte activation status during the course of ACLF, and assess how this associates with disease outcome. By doing paired transcriptional and functional analysis of monocytes isolated at different time-points form recently diagnoses ACLF patients, we aim to profile survivors and non-survivors.
A peripheral blood monocyte gene signature as biomarker for diagnosis of heptatocellular carcinoma Vrije Universiteit Brussel
This study is part of a FWO-NAFOSTED bilateral research project between Flanders and Vietnam.
In view of the high prevalence of HCC in Vietnam, this project will use the network of the Institute of ...
The Monocyte RAGE-LXR-axis as mediator in inflammatory diseases Hasselt University
Monocytic cell heterogeneity: from Trypanosomes to liver pathogenicity and back Vrije Universiteit Brussel
Therefore, a profound understanding of the mechanisms underlying the recruitment and activation of inflammatory cells is crucial to provide the scientific basis for alleviating tissue injury caused by infection or even ...