Projects
Demonstration of yet undiscovered dentrification genes in Gram positive bacteria via whole genome sequencing Ghent University
Denitrification is a redundant enzymatic process. Known denitrification genes could not yet been demonstrated in many gram positive bacteria despite the presence of a clear denitrification capacity. In this project, we will try to underpin the hypothesis that unknown genes are involved in the evolution of fixed nitrogen into nitrogen gas by whole genome sequencing of a selection of denitrifying bacilli.
Combatting Bacterial Resistance in Europe - Molecules Against Gram Negative Infections (COMBACTE-MAGNET). University of Antwerp
Combatting Bacterial Resistance in Europe - Molecules Against Gram Negative Infections (COMBACTE-MAGNET). University of Antwerp
PROTEIN AGGREGATION AS A NEW STRATEGY TO COMBAT GRAM NEGATIVE BACTERIA KU Leuven
Protein homeostasis (proteostasis) is an important key to cell viability and its breakdown can lead to protein misfolding and protein aggregation, which is associated with neurodegenerative diseases. Accordingly, the interruption of bacterial proteostasis was proposed as a valuable drug target. We here present a novel designer antibiotics paradigm that exploits protein aggregation to kill pathogenic E. coli by widespread proteostatic ...
Circuit-Technology Co-optimization of SRAM Design in Advanced CMOS Nodes KU Leuven
The impressive growth of the semiconductor industry in the past few decades has been driven by CMOS technology scaling. Miniaturizing the CMOS devices provides larger integration density, higher performance while lower the power consumption. However, as CMOS scales down to node N5 and beyond, gate length scaling becomes increasingly difficult if not impossible. Furthermore, the resistance of local interconnect in advanced nodes becomes the ...
Energy efficient SRAM design in deep submicron technology KU Leuven
Semiconductor industry has entered deep submicron technology (DSM) these days. Transistors are made very small, providing many opportunities for energy efficient and high speed designs. It has been proven that these transistors can run with ultra high speed. Nevertheless, it is less evident that the same amount of gain is possible in terms of energy efficiency. This Phd tries to explore the energy efficiency possibility with deep submicron ...
Ultra-low Leakage Power SRAM for Biomedical and IoT Applications KU Leuven
The Internet of Things (IoT) has brought about a huge growth in connected smart devices. These devices are mostly battery operated, but have low operating speed requirements, which enables low energy operation. When looking at state of the art microcontroller implementations for these devices, the leakage energy budget of the memory is prominent. This work highlights the significance of leakage optimisation in memories as a key enabler of ...
A flexible SRAM based SEE Radiation Monitor KU Leuven
CERN requires a large number of electronic devices and equipment for its large particle accelerators and colliders such as the Large Hadron Collider (LHC). Since these electronic devices and equipment operate in harsh radiation environments, it is necessary to ensure the proper functionality of these equipment. Therefore, their sensitive components have to pass several experimental tests in a representative environment. For radiation ...