Bayesian methods for the inclusion of historical data in Phase I and Phase II clinical studies Hasselt University
Standard RCTs are analyzed usually by only current data. But, they are costly with respect to trial duration, effort and money, especially due to the number of patients being treated. Moreover, ethical issues are in question that patients who receive placebo are at risk. However, similar historical trials that have been carried out with the same control treatment are available and can be included in the analysis of a new trial. For this reason, ...