Projects
MALDI Mass Spectrometry Imaging (MALDI-MSI): Bridging proteomics and imaging. University of Antwerp
Platform for interdisciplinary isotopic research by means of multi-collector inductively coupled plasma - mass spectrometry Ghent University
As a hybrid mass spectrometer, MC-ICPMS combines an inductively coupled plasma (ICP) plasma source, an energy filter, a magnetic sector analyzer, and multiple collectors for the measurement of ions. The ions are produced by introducing the sample into an inductively coupled plasma which strips off electrons thereby creating positively charged ions. These ions are accelerated across an electrical potential gradient (up to 10 KV) and focused ...
Data Independent Acquisition Mass Spectrometry to Mine Human Stem Cell Histone Epigenetics Ghent University
Epigenetic modifications are essential in the regulation of many biological processes. The histone proteins that are intimately associated with DNA to form the chromatin are pivotal substrates herein. Here, we will apply bottom-up mass spectrometry data independent acquisition strategies to map thousands of PTM in a quantitative manner and to generate a first birdU+2019s eye view of the so-called U+201Chistone codeU+201D.
Comprehensive Liquid Chromatography - Ion Mobility - Quadrupole-Time-of-Flight Mass Spectrometry for innovative metabolomics. University of Antwerp
Pandemic preparedness: developing a multiplexed mass spectrometry assay to screen for pathogens and the induced immune response. Ghent University
The SARS-CoV-2 pandemic has abruptly illustrated the lack of pandemic preparedness. Therefore, health organisations as the WHO have recommended the development of a robust molecular screening platform for early detection and monitoring of the spread of pathogens through the population. This implies supplementing current diagnostic tests like nucleic acid amplification tests (NAATs) with tests targeting other biomolecules, like proteins. ...
Liquid chromatograph interfaced with an isotope ratio mass spectrometry detector (LC-IRMS) Ghent University
The Isotope Bioscience Laboratory (ISOFYS) of the promoter-spokesperson is a centre of excellence holding unique expertise and equipment for analyses and applications of stable isotopes of light elements (H,C,N,O,S) ISOFYS currently manages eight platforms for stable isotope analyses, which foster interdisciplinary collaboration with UGent and (inter)national research groups, as the importance of stable isotopes for (life) science has ...