Belgian Medical Genomics Initiative (BeMGI) Ghent University
The aim of the BeMGI project is to:
(i) understand the biology of disease by exploiting the most advanced genomic tools.
(ii) predict clinical outcome from genomic information and fulfil a pilot role towards concerted integration of genomic information in clinical care in Belgium.
(iii) prepare the next generation of genomics researchers, informing medical practitioners, and conducting public outreach. ...
Next-generation sequencing (NGS) has taken modern research by storm and consequently is one of the most important tools of modern biological and biomedical research. However, the high cost of instrumentation and reagents, the multifaceted expertise required for correct use and the legal and ethical issues hamper access to NGS technologies for many researchers. EASI-Genomics addresses those challenges by unifying the major European genome ...
GENOmics in MEDicine: From whole genome sequencing towards personalized medicine (GENOMED). University of Antwerp
GENOMED - Genomics in Medicine. University of Antwerp
Personalized functional genomics in Mendelian diseases: from DNA variants to clinical and bioethical implications Ghent University
This proposal deals with personalized functional genomics in Mendelian disorders. We will tackle non-U+2010coding variation by NGS approaches. We will use state-U+2010of-U+2010the-U+2010art knockdown, knockout and
rescue experiments in model organisms. Furthermore, functional assays in patient-U+2010derived cellular models such as hiPSCs will lead to understanding of mutations and mechanisms.
In addition, we will ...
NXT-EYE: integrated genomics and transcriptomics for gene identification in inherited retinal degeneration Ghent University
Inherited retinal degeneration (RD) is responsible for 5% of blindness worldwide. Genetic
studies have revealed underlying molecular defects in ~50% of individuals with RD, most of
which are located in the coding portion of the genome. The advent of next-generation sequencing (NGS) has revolutionized the genetic landscape. However, the massive amount of
data produced by NGS hampers disease gene identification, requiring ...
Genomics and innovative induced pluripotent stem cell (iPSC) modeling to improve understanding of pathomechanisms underlying Brugada syndrome (BrS). University of Antwerp
Retinitis pigmentosa: gene discovery and functional analysis through advanced genomics and zebrafish studies Ghent University
The general objective of this project is disease gene discovery in sporadic or autosomal recessive retinitis pigmentosa (RP). Specific objectives are: (1) prescreening of all known RP genes using next-generation sequencing (NGS); (2) identification of new disease genes through homozygosity mapping and NGS of candidate regions; (3) in vivo functional analysis of newly identified RP genes in zebrafish.