Projects
Comparative genomics of pathogenic bacteria KU Leuven
Omics techniques and bioinformatics analyses have become an integral part of modern biological investigation. In this dissertation, we focus on their application to the field of microbiology, more
specifically to the domain of bacteria and their viruses (phages). The work presented can be broadly divided into three sections: i) the development of new bioinformatics methods made possible by the introduction of long read sequencing ...
NXT-EYE: integrated genomics and transcriptomics for gene identification in inherited retinal degeneration Ghent University
Inherited retinal degeneration (RD) is responsible for 5% of blindness worldwide. Genetic
studies have revealed underlying molecular defects in ~50% of individuals with RD, most of
which are located in the coding portion of the genome. The advent of next-generation sequencing (NGS) has revolutionized the genetic landscape. However, the massive amount of
data produced by NGS hampers disease gene identification, requiring ...
Functional genomics in human blood platelets. KU Leuven
Functional genomics of Alzheimer disease: Characterization of the risk effect of progranulin missense mutations. University of Antwerp
Precision genomics in neurodegenerative brain disease: from patients to small model organisms and single cells Ghent University
Precision medicine is emerging as an approach in which individual variability in genes, environment and lifestyle factors are taken into account for personalized treatment, prevention and care. The present research proposal can be placed in the context of precision medicine of rare neurodegenerative brain disorders (NBD). These NBDs constitute a heterogeneous group of ofte
genetic disorders characterized by progressive cognitive and/or ...
Retinitis pigmentosa: gene discovery and functional analysis through advanced genomics and zebrafish studies Ghent University
The general objective of this project is disease gene discovery in sporadic or autosomal recessive retinitis pigmentosa (RP). Specific objectives are: (1) prescreening of all known RP genes using next-generation sequencing (NGS); (2) identification of new disease genes through homozygosity mapping and NGS of candidate regions; (3) in vivo functional analysis of newly identified RP genes in zebrafish.
Single molecule long-read sequencing technology: beyond state-of-the-art in biological and medical research. University of Antwerp
Smartphone crowdsourced medical data for biomedical research: Addressing the ethical, legal and health policy concerns Ghent University
Smartphone applications for health are being increasingly used as a
platform for collecting and sharing large volumes of crowdsourced
personal health data for biomedical research and algorithm training.
Consumer genetics products are similarly allowing individuals to have
direct access to their own genetic data and to share such data ...