Somatic genome instability in Tauopathies: a single cell DNA- and RNA-seq approach in humans, mice and flies to understand the disease aetiology KU Leuven
Somatically acquired genetic variation has been described in mammalian developing as well as elderly brain. It has been suggested that neurons with genetic anomalies due to genomic instability (GIN) accumulate during neurodevelopment, while these aberrant neurons are only partially retained in neurotypical adult and elderly brain following a selection process. Furthermore, the functional impact of these genomic aberrations in neurons and its ...