Projects
Precision medicine in inherited blindness using integrated omics in human and animal models Ghent University
This multidisciplinary project aims (1) to decipher cis-Âregulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-Âbased treatments of novel targets, ultimately resulting in precision medicine ...
Cell-free nucleic acid profiling in diffuse large B-cell lymphoma: a molecular guidance to precision medicine Ghent University
Total RNA sequencing is performed on matched tissue and plasma samples within a human DLBCL cohort to identify (circulating) biomarkers, linked to phenotype, response, and prognosis. Complementary, cell-free RNA (cfRNA) is explored in a patient-derived DLBCL xenograft model, enabling step-by-step dissection of the circulating transcriptome in tumor-, immune-, and stromal cellderived fractions. Lastly, a multi-omics analysis will compare cfRNA ...
Paving the way to precision medicine in childhood-onset diseases: A lifespan perspective on accelerated aging using the epigenetic clock Ghent University
Many childhood-onset diseases used to be lethal. Improved life expectancy yield that most patients can survive into adulthood, to date. However, survivors of childhood-onset diseases often develop morbidities that suggest accelerated aging. Congenital heart disease is a typical example of a childhood-onset disease. It is the most common birth defect, comprising a spectrum of mild, moderate and complex heart defects. Several age-related ...
Making Europe through personalised medicine healthcare KU Leuven
In recent years, the European Union (EU) has targeted Personalised Medicine as a key policy area, increasingly envisaging it as a cornerstone of its innovation strategy. Personalised Medicine has also been adopted as a key focus of health and innovation policy in a number of EU member states. These developments, and the relationship and interactions between them, present a valuable opportunity to investigate the formation and implementation ...
Precision Medicine Technologies (PreMeT) University of Antwerp
Bioinformatics for a high-throughput deep mutational scanning protein-protein interaction assay: turning a prototype into a precision medicine toolbox Ghent University
This proposal contributes to the development of a high-throughput method to characterize the impact of nearly every mutation on specific protein-protein interactions. After bioinformatics-driven experimental optimization, this method will be applied to tumor-driver protein interactions (TP53, PTEN, PIK3R1) and results compared to large-scale tumor mutation and gene expression data. This will allow to demonstrate the major relevance for ...
Reboot Sleep Medicine. University of Antwerp
BOF-ZAP-professorship in veterinary conservation medicine Ghent University
A BOF-ZAP-mandate holder receives an appointment or appointment as a member of the Independent Academic Personnel with mainly research assignment. The wage costs are charged to the resources of the BOF.