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The next generation of transmission electron microscopy: from biomedicine to nanomaterials. A state-of-the art electron microscopy system for cryo-EM and correlative light and electron microscopy. (R-11065) Hasselt University

Ivo LAMBRICHTS
Neurosciences, Materials Physics, Biomedical Research Institute, Zoology: Biodiversity and Toxicology, Cardio & organ systems
This application is submitted by a consortium from different research institutes at Hasselt University in order to reinforce their research lines, to strengthen collaborations within Hasselt University and with external partners. This state-of-the-art infrastructure will enable us to become important (international) players in the field of cryo-EM/CLEM since such infrastructure has only limited presence in Flanders and Belgium. The requested ...

The next generation of transmission electron microscopy: from biomedicine to nanomaterials. A state-of-the art electron microscopy system for cryo-EM and correlative light and electron microscopy (R-10894) Hasselt University

Ivo LAMBRICHTS
Cardio & organ systems
This application was submitted by a consortium from different research institutes at Hasselt University in order to reinforce their research lines, to strengthen collaborations within Hasselt University and with external partners. This state-ofthe- art infrastructure will enable us to become important (international) players in the field of cryo-EM/CLEM since such infrastructure has only limited presence in Flanders and Belgium. The requested ...

Multidisciplinary installation of a polyvalent microscope for transmitted light, phase contrast and fluorescence microscopy KU Leuven

Paul Lambrechts
Biomaterials - BIOMAT, Department of Imaging & Pathology, Periodontology & Oral Microbiology, Orthodontics, Population Studies in Oral Health
Several research lines within the Department of Oral Health Sciences are using light microscopy in several configurations (transmitted light, phase contrast, fluorescence) and they search externally for the observation of histological and microbiological samples and for image digitalisation. However, the screening of slices and samples needs to be performed in close proximity to the place where the samples are prepared, coloured ...

Novel microscope designs for fast and highly adaptable fluorescence microscopy. KU Leuven

Wim Vandenberg
Biochemistry, Molecular and Structural Biology
Due to its high sensitivity and specificity, fluorescence microscopy has been a workhorse technique in (bio-)chemical and medical research for several decades. In recent years, thanks to advances in labeling chemistry, the problems to which this technique can be applied have been strongly diversified. However, the application of these new technologies in 3D rather than 2D microscopy has been limited, at least in part due to a lack ...

3D super-resolution correlative light and electron microscopy on a dedicated CLEM microscope and development of an automated data acquisition KU Leuven

Natalia Gunko
Research Group Molecular Neurobiology (VIB-KU Leuven)

Fluorescence microscopy can provide information about location of specific protein molecules, by tagging them with fluorescent moieties, or by labeling them with fluorescent antibodies. However, this information is constraint by the limited resolution of the fluorescence microscope as well as by the absence of cellular context on the nano-scale. Therefore it is necessary to employ correlative light and electron microscopy (CLEM), which ...

Disposable sample holder with integrated optics for enabling Light Sheet Microscopy on standard light microscopes Ghent University

Elisa Zagato
Department of Pharmaceutics

The human body is a true wonder. It is composed by an average of A.G trillion cells, subdivided in more than MNN different cell types, each with its function and its own specialization. Yet, life is possible only if those cells manage to communicate and closely collaborate with each other, to reach their common goal. Clearly, collaboration is the key to evolution and progress. This is no different in science. The technological progresses of ...

Research in the field of the advanced biomedical microscopic imaging: "Towards medical cytomics. Paving the way with nextgeneration microscopy". University of Antwerp

Winnok De Vos
Laboratory of cell biology and histology
The techniques for monitoring and manipulating cells have reached a level of maturity that allows them to be implemented in high-level biological research. The promotor wants to grasp this momentum and raise the standard in modern microscopy technology while connecting cellular phenotypes with disease development.From a biological perspective, it is the goal to elucidate the mechanisms underlying cellular dysfunction in the context of genetic ...

Full field optical coherence microscopy (FF-OCM) with ultrahigh resolution for 3D microscopic monitoring of biological tissues. KU Leuven

Wouter Saeys
Division of Mechatronics, Biostatistics and Sensors (MeBioS)
Visualization and measurement of the tissue structure are crucial to understand the development of biological systems. Conventional optical microscopy can only obtain 2D structure images of sliced biological tissue samples. Optical coherence tomography (OCT) is a noninvasive 3D optical imaging technique for biological tissues. Thanks to the low coherence of the broadband light sources, OCT allows cross-sectional imaging of biological tissues ...

Symmetry Point Group Determination Using Third Harmonic Generation Microscopy KU Leuven

Thierry Verbiest
Molecular Imaging and Photonics, Chemistry, Kulak Kortrijk Campus

This PhD will focus on multiphoton microscopy, a technique based on nonlinear optics to gain structural insights into bulk samples. Using high intensity infrared lasers, a wide variety of samples, such as biological tissue or crystals, can be probed, resulting in optical responses known as second and third harmonic generation (SHG and THG), where the emitted light frequency will be double or triple the frequency of ...

In situ investigation of biochemical and nanocolloidal dynamics using fast optical nanoscopy: Video rate high resolution fluorescence microscopy in material science and biochemistry. KU Leuven

Johan Hofkens
Molecular Imaging and Photonics

Nanomaterials are all around us. They are widely used as they show some extraordinary properties as catalysts (showing unexpected reactivity or needing less starting material), as additives to change properties of bulk materials (exhibiting luminescent properties like in quantum dots, or altering wetting behavior for self cleaning effect), biomedical applications for target drug delivery, potential investigation ...