Publications
Advances in organic polymer-based monolithic column technology for high-resolution liquid chromatography-mass spectrometry profiling of antibodies, intact proteins, oligonucleotides, and peptides Vrije Universiteit Brussel
Modeling the effect of species retention on the band broadening in perfectly ordered silica monolithic column mimics with variable external porosity and intra-skeleton diffusivity Vrije Universiteit Brussel
Optimized mobile phase for CEC of acetylsalicylic acid and its impurities using a methacrylate-based monolithic column Vrije Universiteit Brussel
The potential of polymer monolithic column technology in combination with high-resolution mass spectrometry for the analysis of proteins isoforms Vrije Universiteit Brussel
Monolithic silica xerogel capillary column for separations in capillary LC and pressurized capillary electrochromatography Vrije Universiteit Brussel
Selection of column dimensions and gradient conditions to maximize the peak-production rate in comprehendive off-line two-dimentional liquid chromatography using monolitihic columns Vrije Universiteit Brussel
Performance of small-domain monolithic silica columns in nano-liquid chromatography and comparison with commercial packed bed columns with 2 µm particles Vrije Universiteit Brussel
We report on a direct comparison of the separation performance in capillary nano-LC between commercial packed bed columns and the small-domain silica monoliths in applications. Octadecylsilylated monolithic silica capillary columns with a 50 and 100 µm inner diameter (i.d.) were prepared with a procedure providing domain sizes in the sub-2 µm range. The fabricated monolith columns could provide plate heights (H) of 4.0‒4.2 µm for hexylbenzene ...
Performance of functionalized monolithic silica capillary columns with different mesopore sizes using radical polymerization of octadecyl methacrylate Vrije Universiteit Brussel
We report on the possibility to enhance the phase ratio and retention factor in silica monoliths. According to pioneering work done by Núñez et al. [1], this enhancement is pursued by applying a stationary phase layer via radical polymerization with octadecyl methacrylate (ODM) as an alternative to the customary octadecylsilylation (C18-derivatization). The difference in band broadening, retention factor and separation selectivity between ...
Evaluating micellar liquid chromatographic methods on octadecyl particle-based and monolithic columns to predict the skin permeation of drug and cosmetic molecules Vrije Universiteit Brussel
A micellar liquid chromatographic method was developed to assist in the modeling of the skin permeability of pharmaceutical and cosmetic compounds. The composition of the mobile phase was determined by means of a two-factor central composite design, after which it was tested on both a particle-based and monolithic column. The latter provided the opportunity to increase the flow rate from 1 to 8 mL/min without reaching too high backpressures. ...