Projects
Exploring the role of DPP6 loss and hyperexcitability in neurodegenerative brain diseases. University of Antwerp
Wireless brain monitoring stimulation tools to investigate neurodegenerative diseases KU Leuven
There is growing evidence that in people with neurodegenerative diseases, like dementia and Parkinson, wide-spread changes in functional brain connectivity occur much earlier than clinically relevant symptoms of the disease. A key requirement in the development of early predictive models as well as novel interventions targeting synaptic and neuronal integrity is the ability to reliably measure brain function in a natural environment during ...
BEyOND: Brain pEt to Overcome Neurodegenerative Diseases. KU Leuven
BEyOND trains ESR fellows in innovative approaches to develop quantitative brain PET imaging for better patient care and accelerated drug development for neurodegenerative diseases. Brain disorders are a major public health problem in Europe, and pharmaceutical drugs are the predominant therapeutic approach. In order to manage the constantly increasing healthcare and drug development costs, there is an urgent need for next-generation ...
Precision genomics in neurodegenerative brain disease: from patients to small model organisms and single cells Ghent University
Precision medicine is emerging as an approach in which individual variability in genes, environment and lifestyle factors are taken into account for personalized treatment, prevention and care. The present research proposal can be placed in the context of precision medicine of rare neurodegenerative brain disorders (NBD). These NBDs constitute a heterogeneous group of ofte
genetic disorders characterized by progressive cognitive and/or ...
Blocking immune cell migration into the brain: a targeted therapy for autoimmune and neurodegenerative diseases Hasselt University
Precision genomics in neurodegenerative brain disease: from patients to small model organisms and single cells Ghent University
We will study genomic aspects of rare neurodegenerative brain disorders (NBD). First, we will establish a multidisciplinary clinical neurogenetics program at UZ Gent. Second, we will use fruit flies to study the potential pathogenic nature of novel NBD-related genetic variants. Third, we will use single-cell sequencing to study the role of genomic mosaicism in neurodegeneration.
The eye as a window to the brain - a quest for retinal biomarkers in neurodegenerative disease KU Leuven
Because of a shared ontogenic origin, the retina displays similarities to the brain and spinal cord in terms of anatomy, functionality, response to insult, and immunology. Hence, the retina can be approached as an integral part of the central nervous system. The occurrence of ocular manifestations in several neurodegenerative pathologies, such as Alzheimer's disease disease, accentuates the strong relationship between eye and brain. ...