Projects
MOLECULAR DESIGN OF U+2018FROZENU+2019 APTAMERS: Aptamers with enhanced properties by covalent and non-covalent stabilization using functionalized nucleotides: a combined modelling, NMR and electrochemistry approach Ghent University
De on-site en zeer selectieve detectie van cocaïne en andere belangrijke doelanalyten zoals
antibioticaresiduen in afvalwater blijven een uitdagend onderzoeksgebied. In dit project willen we dat
beter begrijpen en uiteindelijk verbeteren van analytische detectiesystemen die kort DNA gebruiken
sequenties voor selectieve herkenning van interessante moleculen - aptamers genaamd - gevolgd door de
generatie van elektrische ...
Molecular design of 'Frozen Aptamers': Aptamers with enhanced properties by covalent and non-covalent stabilization using functionalized nucleotides: a combined modelling, NMR and electrochemistry approach. University of Antwerp
New NMR methods to study supramolecular self-assemblies - application to the structure-function relation of cyclic lipodepsipeptides Ghent University
New NMR methods to study supramolecular assemblies will be developed. The approaches will mainly rely on translational diffusion and heteronuclear relaxation measurements. These methods will be applied to an in depth investigation of the antimicrobial cyclic lipodepsipeptides and more specifically to the relation between their self-assembly properties, their monomer and supramolecular structure and their biological activity.
The Determination of transport properties in carbonate rocks with high-resolution CT and NMR. KU Leuven
Continental carbonates are studied because of their reservoir potential. Especially with the recent discovery of microbialite and travertine oil fields in the Pre-Salt (offshore Brazil) and in the Namibe basin (Angola), the importance of continental carbonates as reservoir rocks for future hydrocarbon production was highlighted. Quaternary continental carbonates from quarries in Denizli (Turkey) and from Sütt# and Budakalász (Hungary) were ...
Development and application of NMR diffusion and relaxation techniques for the characterisation of supramolecular structures and self-assembly Ghent University
New NMR techniques, based on diffusion and relaxation measurements, will be developped to study supramolecular assemblies. These will be applied within the framework of the structure-function relationship study of synthetic variants of the biological active pseudodesmin A, a self-assembling cyclic lipodepsipeptide. Furthermore, the impact of biomolecular self-association on the relaxation parameters and the impact on dynamics studies will be ...
Structure-function study with NMR of and insight into the supramolecular assembly of lipopeptide antibiotics from the viscosin group. Ghent University
The relation between monomer structure, supramolecular assembly and the resulting biological function of self-assembling antimicrobial lipopeptides will be studied. The recently shown potential of diffusion relaxation NMR techniques to gain information about the self-assembly will be employed. Next to this, we wish to synthesize a series of non-natural variants, which will elucidate the principles of the self-assembly.
In-situ observation and manipulation of ligands of colloidal quantum dots using liquid NMR Ghent University
This project plans to further develop and apply NMR spectroscopy to obtain fundamental insight in the surface chemistry between organic ligands and nanoparticles in colloidal dispersions
Structure elucidation of synthetic compounds and natural products by NMR and LC-NMR spectroscopy. University of Antwerp
Application of STD NMR Techniques For The Discovery of Small Molecule Modulators For VWF-A1-GPIb alpha Interaction KU Leuven
In this fragment based ligand design project we plan to use the technique of STD-NMR to identify weak binders for different ...