Publications
A case report of a novel NTRK gene fusion in pleomorphic xanthoastrocytoma University of Antwerp
Immunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial University of Antwerp KU Leuven
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib University of Antwerp KU Leuven Ghent University Hasselt University
Detection of NTRK Fusions and TRK Expression and Performance of pan-TRK Immunohistochemistry in Routine Diagnostics: Results from a Nationwide Community-Based Cohort University of Antwerp
NTRK fusions in a sarcomas series University of Antwerp
Identification of a novel PHIP::BRAF gene fusion in infantile fibrosarcoma KU Leuven
NTRK Fusions in Sarcomas: Diagnostic Challenges and Clinical Aspects Vrije Universiteit Brussel University of Antwerp
Tropomyosin receptor kinase (TK) is encoded by the neurotrophic tyrosine receptor kinase genes (NTRK) 1, 2, and 3, whose activation plays an important role in cell cycle proliferation and survival. Fusions of one of these genes can lead to constitutive activation of TRK, which can potentially be oncogenic. NTRK fusions are commonly present in rare histologic tumor types. Among sarcomas, infantile fibrosarcoma shows NTRK fusion in more than ...
Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network KU Leuven
Targetable Gene Fusions Identified in Radioactive Iodine-Refractory Advanced Thyroid Carcinoma Vrije Universiteit Brussel
OBJECTIVE: Gene alterations leading to activation of the MAPK pathway are of interest for targeted therapy in patients with advanced radioactive iodine-refractory (RAI-R) thyroid carcinoma. Due to technical reasons gene fusion analysis in RNA isolated from formalin-fixed tumor tissues has till now been limited. The objective of the present study was to identify targetable gene rearrangements in RNA isolated from formalin-fixed RAI-R thyroid ...