Projects
Noninvasive neuromodulation: Animal models to understand basic neural mechanisms KU Leuven
Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method in which DC current is passed through scalp electrodes with the aim of altering brain activity. The current passes through the scalp, skull, and cerebrospinal fluid (CSF), before a small fraction reaches the brain. The recent surge in interest, combined with tDCS noninvasive nature and low-cost, mean that a wide range of potential clinical applications are ...
Soft optoelectronics and ion-based circuits for diagnostics and closed-loop neuromodulation of the auditory pathway Ghent University
Understanding and modulating neural networks requires high-resolution acquisition of neural activity over time, real-time analysis, and minimally invasive stimulation methods with high specificity. Such procedures are particularly needed for treatment of sensory disfunction (e.g. hearing loss), and certain neurological diseases (e.g. epilepsy). The lack of soft, biocompatible, hybrid and smart neural interfaces hinders our capacity to study ...
New hydrogel-based, soft waveguides for optical neuromodulation Ghent University
Optical neuromodulation techniques, like optogenetics and photopharmacology, as a treatment for neurological disorders have two major advantages in comparison to other neuromodulation techniques: a very high spatiotemporal resolution and cell-type specificity. A major hurdle for the practical use of optical neuromodulation techniques is the mechanical mismatch between soft neural tissue and stiff optical probes, leading to a severe Foreign ...
Research line management for Neuromodulation and Immunopsychiatry University of Antwerp
Neuromodulation for central post-stroke pain: mechanism, safety and outcome KU Leuven
Approximately 8% of stroke patients develop central post stroke pain (CPSP). CPSP is a specific type of neuropathic pain, resulting directly from an ischaemic or haemorrhagic brain injury along the pain circuitry. CPSP is usually severe and chronic, and has a profound impact on quality of life, sometimes even leading to suicidality. Although there is level 1 evidence for several neuropathic analgesics, the numbers needed to treat are high, ...
Neuromodulation for central post-stroke pain: mechanism, safety andoutcome. KU Leuven
Explanatory multi-compartmental computational model for the underlying mechanisms of ultrasonic neuromodulation Ghent University
In the last decade, ultrasonic neuromodulation (UNMOD) has gained significant attention, because of its capability to modulate cortical or deep neuronal activity non-invasively, selectively, reversibly, and with millimeter resolution. These favourable properties make UNMOD a promising alternative to state-of-the-art electrical neurostimulation technologies, that require surgery to reach deep targets (deep brain stimulation) or are restricted ...
Neuromodulation for central post-stroke pain: mechanism, safety and outcome. KU Leuven
Central post-stroke pain (CPSP) is an often pharmacorefractory type
of neuropathic pain that develops in 8% of stroke patients. CPSP has
been treated with three distinct types of neuromodulation (deep brain
stimulation of the sensory thalamus (Vc-DBS), motor cortex repetitive
transcranial magnetic stimulation (M1-rTMS), and motor cortex
stimulation (MCS)), but the level of evidence for these procedures is
very ...