The early embryonic function of TET DNA dioxygenases in human neurulation and disease. KU Leuven
TET family dioxygenases erase DNA methylation. Loss of Tet1 in the pre-gastrulation mouse epiblast causes dysregulation of chromatin accessibility and DNA methylation at neural fate genes prior to their gene activation in development, resulting in congenital and post-natal neurodevelopmental disorders in mutant mice. Here, we aim to extend our findings from mouse to human development, by exploiting in vitro differentiation of human embryonic ...