Projects
Distribution and transport of uremic retention solutes: from modelling towards optimisation of hemodialysis Ghent University
Kinetic models for different retention solutes like the protein-bound solutes are calibrated and validated based on in vitro and in vivo data. These models are further used to develop a new parameter to indicate hemodialysis adequacy as well as to optimise and personalise the hemodialysis treatment.
Optimisation algorithms for plant breeding Ghent University
This research focusses on several problems from plant breeding which can be expressed in a mathematical model (e.g. using graphs) and which are suited for combinatorial optimisation. Among others, algorithms are developed for the selection of representative core subsets sampled from large plant collections, for the optimisation of crossing schedules using genetic markers and for the creation of heterotic pools.
Integrating search and optimisation technology for formal modelling languages. KU Leuven
Several research fields share the goal of developing domain independent languages and techniques for search and optimisation. Main-stream areas are operations research, constraint programming and satisfiability checking of propositional logic. A new development is the emergence of search systems based on expressive logics with origins in the area of knowledge representation that prove well-suited in knowledge-intense domains. This approach ...
Design and optimisation of synthetic DNAzymes: development of an integrated structure analysis approach Ghent University
Catalysis plays an essential role in modern chemical research and in the chemistry of life. It allows creating complex molecular structures and enables and accelerates transformations. A billion years of evolution has allowed the development of protein based enzymes as natural catalysts with high efficiency and selectivity. The creation of artificial catalytic systems inspired by nature has now become a timely human endeavor. DNA represents a ...
Numerical methods for parametric dynamic optimisation of (bio)chemical processes KU Leuven
This project deals with parametric optimisation of large-scale (bio)chemical processes, i.e., calculating the solution path of an optimisation problem as a function of one or more varying parameters. Typical examples include heat transfer coefficients (which change when fouling occurs), design parameters (e.g., dimensions) and operational parameters (e.g., maximal admissible reactor temperature).
As ...
Model-based optimisation of the trade-offs between biomass production, climate feedback and water consumption in short rotation coppice forestry. University of Antwerp
Optimisation of the treatment of rectal cancer in patients by combining preoperative chemoradiation with angiogenesis inhibitors. KU Leuven
Robust modelling and optimisation in stochastic processes using impreciseprobabilities, with applications to queueing Ghent University
A process is called stochastic when its time-evolution is to some
extent uncertain. To model and reason with such uncertainty, we
use methods from probability theory. This allows us to analyse the
behaviour of these processes, and to design or influence them in
order to make their behaviour optimal or desirable.
One crucial problem is that most often we are not only uncertain
about the processes themselves, but ...