The role of the paraoxonase gene family in obesity and obesity-associated liver disease following exposure to environmental pollutants or medical intervention strategies. University of Antwerp
With more than 650 million patients worldwide and a prevalence that will only increase further, obesity has become one of the biggest health-threats of the 21st century. Obesity is such a big problem because it induces a systemic inflammation that causes a lot of co-morbidities including cardiovascular disease and cancer. The biggest risk factor for obesity and obesity-associated inflammation is a western diet, high in fat and carbohydrates. ...
Obesity is a global pandemic, currently affecting around 150 million people in Europe and 650 million people worldwide. Obesity complications are common, in fact obesity is associated with some 200 complications, but we cannot yet predict who will develop the complications of obesitybe affected. Moreover, there are no predictors for who will respond to obesity treatments. SOPHIA will therefore identify and characterise clinically-meaningful ...
The role of adipose tissue hypoxia in obesity and obstructive sleep apnea. University of Antwerp
Unraveling the Role of Paraoxonase 1 and 3 in the Etiology and Progression of Obesity and Obesity-Associated Liver Disease University of Antwerp
A search for better insights and new targets in the prevention and reversal of obesity and type 2 diabetes. KU Leuven
Endocrine-disrupting environmental chemicals: From accumulation to their role in the global "neuro-endocrine" epidemic of obesity and its metabolic consequences. University of Antwerp
Linking patient adiposity to tumour microenvironment and therapy response in breast cancer: towards tailored treatment strategies in obesity KU Leuven
Over the past decades we have seen a worldwide health problem
emerging: obesity. It is well known that overweight and obesity
increase the risk of developing heart diseases, diabetes and several
cancers including breast cancer. Additionally, obesity has been
associated with an increased risk of recurrence in breast cancer
patients. Nevertheless, many unknowns remain, such as the exact
composition of the ...
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease caused by dysfunction or absence of ADAMTS13 (A Disintegrin And Metalloproteinase with ThromboSpondin type one motif, member 13), which cleaves prothrombotic ultralarge von Willebrand factor multimers (UL-VWF), thereby preventing the formation of platelet-rich microthrombi that block capillaries and arterioles, which leads to organ failure and death. Concerning the ...