Pharmacogenetic Determinants of Tacrolimus Disposition and the Effects in Renal Transplant Organs and Recipients KU Leuven
The success of kidney transplantation is largely carried by the efficacy of CNIs. Until now no new immunosuppressive drugs have performed better than tacrolimus in large randomized trials. Because of its success, it will be difficult setting up trials with a sufficient number of patients and duration of follow-up to find new CNI-free immunosuppressive regimes with a superior long-term outcome. Nevertheless, tacrolimus is not a drug easy to ...