Publications
Chosen filters:
Chosen filters:
The role of cellular oxidoreductases in viral entry and virus infection-associated oxidative stress: potential therapeutic applications KU Leuven
Cellular oxidoreductases catalyze thiol/disulfide exchange reactions in susceptible proteins and contribute to the cellular defense against oxidative stress. Oxidoreductases and oxidative stress are also involved in viral infections. In this overview, different aspects of the role of cellular oxidoreductases and oxidative stress during viral infections are discussed from a chemotherapeutic viewpoint. Areas covered: Entry of enveloped viruses ...
Ss-LrpB, a transcriptional regulator from Sulfolobus solfataricus, regulates a gene cluster with a pyruvate ferredoxin oxidoreductase operon and permease genes Vrije Universiteit Brussel
Ss-LrpB is an Lrp-like transcriptional regulator from Sulfolobus solfataricus. Previously, in vitro binding of Ss-LrpB to the control region of its own gene has been extensively studied. However, nothing was known about the physiological role of this regulator yet. Here, using the knowledge of the DNA-binding sequence specificity of Ss-LrpB, several potential binding sites were predicted in silico in promoter regions of genes located adjacently ...
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity Flanders Institute for Biotechnology KU Leuven
MHC class II-restricted epitopes containing an oxidoreductase activity prompt CD4+ T cells with apoptosis-inducing properties KU Leuven
Abrogating an unwanted immune response toward a specific antigen without compromising the entire immune system is a hoped-for goal in immunotherapy. Instead of manipulating dendritic cells and suppressive regulatory T cells, depleting effector T cells or blocking their co-stimulatory pathways, we describe a method to specifically inhibit the presentation of an antigen eliciting an unwanted immune reaction. Inclusion of an oxidoreductase motif ...
The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients KU Leuven
Recently a SNP of the gene encoding P450 oxidoreductase (POR*28; rs1057868C>T) has been associated with increased in vivo CYP3A activity using midazolam as a drug probe. Because tacrolimus is metabolized by CYP3A isoenzymes, this SNP might affect tacrolimus pharmacokinetics.
A salivary GMC oxidoreductase of Manduca sexta re-arranges the green leaf volatile profile of its host plant Ghent University
Green leaf volatiles (GLVs) are short-chain oxylipins that are emitted from plants in response to stress. Previous studies have shown that oral secretions (OS) of the tobacco hornworm Manduca sexta, introduced into plant wounds during feeding, catalyze the re-arrangement of GLVs from Z-3- to E-2-isomers. This change in the volatile signal however is bittersweet for the insect as it can be used by their natural enemies, as a prey location cue. ...
rbohA, a rice homologue of the mammalian gp91phox respiratory burst oxidase gene Meise Botanic Garden
It has been hypothesized that plants contain respiratory burst oxidases which, upon activation, oxidize NADPH and generate extracellular superoxide, O2·-. These proteins are proposed to play a central role in defence against pathogens. However, plant DNA sequences that encode proteins with similarity to components of respiratory burst oxidases have not previously been reported. This paper describes the complete cDNA and genomic DNA sequence of ...