The NEAT1-paraspeckles pathway as a potential target for RNA-based cancer therapeutics. KU Leuven
NEAT1 is a well-conserved, highly expressed nuclear RNA that does not code for proteins. It exists in two isoforms of 3.7 and 22.7 kb, of which the longer is the essential architectural component of a nuclear body in the cell, the paraspeckle.
In this thesis, we show that the tumor suppressor p53 upregulates NEAT1 transcription leading to the formation of paraspeckles in cultured cells, in mouse skin, and in human ...