Projects
Motion compensation for PET in TOF-PET/CT and TOF-PET/MR brain imaging KU Leuven
Motion compensation for PET in TOF-PET/CT and TOF-PET/MR brain imaging KU Leuven
In PET/CT or PET/MR brain imaging, images of the metabolism and anatomy of the patient are acquired. If the patient moves during the PET acquisition, then motion blurring is caused, the image quality is deteriorated, and an accurate clinical diagnosis might become impossible. Several research groups (including our own) have previously developed marker based methods to track the motion of the head, such that the motion can be compensated for ...
Prototyping and validation of a system for unrestrained awake brain PET imaging of small laboratory animals. University of Antwerp
PET imaging of free running rats with a high resolution human scanner for simultaneous behavioral neuroscience and imaging University of Antwerp
BEyOND: Brain pEt to Overcome Neurodegenerative Diseases. KU Leuven
BEyOND trains ESR fellows in innovative approaches to develop quantitative brain PET imaging for better patient care and accelerated drug development for neurodegenerative diseases. Brain disorders are a major public health problem in Europe, and pharmaceutical drugs are the predominant therapeutic approach. In order to manage the constantly increasing healthcare and drug development costs, there is an urgent need for next-generation ...
Prospective longitudinal MRI and PET studies of epileptogenesis and brain plasticity in epilepsy using [18F]fluorodeoxyglucose (FDG), [18F]flumazenil (FMZ), [18F]MK-9470 in small animals with epilepsy. KU Leuven
Preclinical PET imaging of allele-selective mHTT lowering as candidate treatment for Huntington's Disease. University of Antwerp
Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp
PET imaging of the mGluR5 receptor in addiction: its role in deficient corticostriatal control and glutamatergic modulation of dopaminergic neurotransmission KU Leuven
Addiction is a complex brain disorder, leading to a compulsive obsession to use a substance despite serious detrimental consequences. Apart from a dysfunctional reward system, reduced inhibitory corticostriatal control in drug-seeking and drug-taking1 and vulnerability to addiction2 has been emphasized. Genetic, developmental, and environmental factors are major contributors to addiction risk, but the neurobiological processes that underlie ...