Projects
BEyOND: Brain pEt to Overcome Neurodegenerative Diseases. KU Leuven
BEyOND trains ESR fellows in innovative approaches to develop quantitative brain PET imaging for better patient care and accelerated drug development for neurodegenerative diseases. Brain disorders are a major public health problem in Europe, and pharmaceutical drugs are the predominant therapeutic approach. In order to manage the constantly increasing healthcare and drug development costs, there is an urgent need for next-generation ...
Development of novel cell death PET imaging probes for early treatment response assessment. University of Antwerp
Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp
Molecular imaging for early response assessment of drugs targeting the PI3K/mTOR pathway in an HER-2 amplified breast cancer model. University of Antwerp
Molecular and functional imaging as a pivotal tool for translational medicine in the field of neuroscience and oncology: a platform creating a bridge between basic research, clinical development and industrial application. KU Leuven
Algorithms for anatomy-guided image reconstruction in nuclear medicine tomography. KU Leuven
Innovative concepts for PET-MR imaging of brain function and brain-gut interactions KU Leuven
PET imaging is extremely useful in the early phase of drug development as changes in intensity of the PET signal can quantitatively reflect dynamic target occupancy by drugs. In this way, PET imaging can be used to optimize the dose regimes of new drugs such that specific levels of target occupancy are achieved, and efficacy is improved in later phase clinical trials. The current project focusses on validating new PET radiotracers as ...
Rigid Motion Correction for Positron Emission Tomography Brain Imaging KU Leuven
During a positron emission tomography (PET) scan the subject is required to be completely stationary for the duration of the scan. Any motion of the subject will translate into motion blur in the final reconstructed image and may reduce the diagnostic value of the image. Motion during a PET scan can be classified into two main categories: non-rigid and rigid motion. Non-rigid motion deforms the subject and is primarily caused by motion in the ...