Projects
Multicenter validation trial of [18F]AlF-FAPI-74 for PET imaging of cancer-associated fibroblasts through fibroblast activation protein inhibitors (FAPI) in digestive tumors KU Leuven
This project will study in the diagnostic accuracy of a novel positron emission tomography (PET) tracer ([18F]AlF-FAPI74) targeting fibroblast activation protein (FAP) in a prospective, non-randomized, multicenter, multi-cohort, interventional phase II/III trial. FAP is a promising emerging molecular target, expressed on cancer-associated fibroblasts and is independent of cancer cell characteristics such as tumoral glycolytic phenotype and ...
Motion compensation for PET in TOF-PET/CT and TOF-PET/MR brain imaging KU Leuven
In PET/CT or PET/MR brain imaging, images of the metabolism and anatomy of the patient are acquired. If the patient moves during the PET acquisition, then motion blurring is caused, the image quality is deteriorated, and an accurate clinical diagnosis might become impossible. Several research groups (including our own) have previously developed marker based methods to track the motion of the head, such that the motion can be compensated for ...
Motion compensation for PET in TOF-PET/CT and TOF-PET/MR brain imaging KU Leuven
Low dose, high resolution Ga-68 PET imaging for oncological indications KU Leuven
Positron Emission Tomography (PET) is a medical imaging modality measuring the in vivo processes of cells and molecules using radiotracers. Compared to other medical imaging techniques, PET still suffers from limited spatial resolution and signal-to-noise ratio. One key factor to resolution degradation is the distance the emitted positron travels before annihilating with an electron. This distance is called positron range. Radionuclides ...
Preclinical PET imaging of allele-selective mHTT lowering as candidate treatment for Huntington's Disease. University of Antwerp
PET imaging of the somatostatin receptor and norepinephrine transporter in neuroendocrine and neural crest tumors for better radionuclide therapy selection KU Leuven
Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that develop from cells of the diffuse (neuro)endocrine system. Many NETs show an overexpression of the somatostatin receptor (SSTR), which represents an ideal target for molecular imaging and radionuclide therapy with radiolabeled somatostatin analogues (SSAs). [68Ga]Ga-DOTA-SSA PET, the current gold standard for SSTR imaging, faces challenges such as high cost, limited ...
[18F]AlF-NOTA-octreotide PET imaging of the somatostatin receptor in neuroendocrine tumors: comparison with [68Ga]Ga-DOTATATE and evaluation of routine clinical use. KU Leuven
Data-driven brain and heart PET imaging of awake rodents. University of Antwerp
Deep Learning Enhanced 4D Total Body PET Imaging Ghent University
The extended axial field-of-view (FOV) of so-called total-body positron emission tomography (PET) scanners provides an opportunity to image the dynamic radiopharmaceutical distribution across multiple organs at the same time. Parametric maps can be derived from 4D TB-PET data through kinetic modelling analyses, and these images can offer clinicians additional insight on how to guide and manage treatment. However, the implementation of dynamic ...