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Chemotherapy drug shortages in paediatric oncology University of Antwerp KU Leuven
Shortages of chemotherapy are a growing challenge for the healthcare system. We present the burden of drug shortages of chemotherapeutics in the paediatric hemato-oncology unit of a tertiary care hospital and solutions that were used to manage them. Between January 2001 and December 2014, 54 individual shortages were detected, affecting a total number of 21 different drugs. In total, 4127 shortage days were registered with a mean duration of ...
TEARDRoP oncology : good practices for paediatric biobanking Ghent University
With the support of the Olivia Hendrickx Research Fund, the ‘Team EARly DRug development in Paediatric oncology (TEARDRoP)’ consortium was founded to support the translation of new research findings in the field of pediatric oncology to new therapeutic options, making science find its way to children in need of new and better treatments. In specific, the consortium aims to support biobanking efforts through a bottom-up approach by: (i) bringing ...
Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Ne University of Antwerp Ghent University
Introduction: Neuroblastoma, the commonest paediatric extra-cranial tumour, remains a leading cause of death from cancer in children. There is an urgent need to develop new drugs to improve cure rates and reduce long-term toxicity and to incorporate molecularly targeted therapies into treatment. Many potential drugs are becoming available, but have to be prioritised for clinical trials due to the relatively small numbers of patients. Areas ...
Contemporary paediatric radiation oncology Ghent University
Treatment with ionising radiation is a valuable component of treatment schedules for a many children and young people with cancer. While some form of radiotherapy has been in use for over 100 years, a series of innovations has revolutionised paediatric radiation oncology. Mostly, high-energy X-ray photons are used, but proton beam radiotherapy is increasingly offered, especially in children and young people. This is to reduce the radiation ...
The implementation of a national paediatric oncology protocol for neuroblastoma in South Africa University of Antwerp
Purpose The aim of the World Health Organization-International Paediatric Oncology Society is to improve childhood cancer survival in low- and middle-income countries to 60% by 2030. This can be achieved using standardised evidence-based national treatment protocols for common childhood cancers. The aim of the study was to describe the development and implementation of the SACCSG NB-2017 neuroblastoma (NB) treatment protocol as part of the ...
Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials KU Leuven
The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, ...
Interweaving vulnerability and everyday design: Encounters around an aquarium in a paediatric oncology ward KU Leuven
Contemporary understandings of vulnerability highlight its critical, relational and enabling aspects. Through leveraging these understandings, this article contributes to conceptualizing the notion of everyday design by interweaving it with that of vulnerability. A case study brings vulnerability into view by zooming out from and in on everyday practices around an aquarium in a paediatric oncology ward. Subsequently, we unravel the notion of ...