Synaptic dysfunction in Parkinson’s disease and neurodegeneration. KU Leuven
Parkinson’s disease is an incurable neurodegenerative, lethal movement disorder affecting ~10 million people. Familial disease is caused by mutations in >20 genes and these map to a limited number of diverse molecular pathways. Using new and extensive collections of fruit flies and iPS cells we are studying the mutations in these genes that cause disease, with the ultimate goal to understand the underlying pathogenic pathways. In addition, ...