The effect of synaptic activity on alpha-synuclein pathogenesis in a model for Parkinson's Disease KU Leuven
Parkinson’s disease (PD) is the most frequent neurodegenerative movement disorder, affecting about 1% of the population over 60. The increase in life expectancy is estimated to double the prevalence of PD in 20 years, expanding the personal, medical and economic burden. Alpha-synuclein (a-SYN) aggregates are found in the brain of PD patients, but this important hallmark is also present in other neurodegenerative disorders, like multiple ...