Identification and characterization of novel compounds that can alleviate mitochondrial dysfunction using yeast as a model KU Leuven
Mitochondrial dysfunction is related to various human pathologies including inborn errors of mitochondrial metabolism such as Lebers hereditary optic neuropathy, age-related neurodegenerative disorders such as Alzheimers disease and Parkinsons disease but also rare diseases such as Wilson disease and Niemann Pick disease type C1. In addition, mitochondrial dysfunction is not exclusively related to inborn/acquired mutations, but can also be ...