Publications
The effect of intensive speech rate and intonation therapy on intelligibility in Parkinson's disease Vrije Universiteit Brussel Ghent University University of Antwerp
Transcranial direct current stimulation in Parkinson's disease: Neurophysiological mechanisms and behavioral effects. Hasselt University KU Leuven
System xc- as a possible novel target for the treatment of limbic epilepsy and Parkinson's disease Vrije Universiteit Brussel
Mutations in glucocerebrosidase are a major genetic risk factor for Parkinson's disease and increase susceptibility to dementia in a Flanders-Belgian cohort Vrije Universiteit Brussel University of Antwerp
OBJECTIVE: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations.
METHODS: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well-characterized PD patients and 536 healthy control individuals.
RESULTS: We identified rare, heterozygous GBA mutations in 12 PD patients (4.5%) and in 2 ...
Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease Vrije Universiteit Brussel University of Antwerp
Early genome-wide association (GWA) studies on Parkinson's disease (PD) have not been able to yield conclusive, replicable signals of association, perhaps due to limited sample size. We aimed to investigate whether association signals derived from the meta-analysis of the first two GWA investigations might be replicable in different populations. We examined six single-nucleotide polymorphisms (SNPs) (rs1000291, rs1865997, rs2241743, ...
Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients Vrije Universiteit Brussel University of Antwerp
We determined the prevalence of mutations in two major functional domains of the leucine-rich repeat kinase 2 gene (LRRK2) in Belgian Parkinson's disease (PD) patients (N=304) of which 18.1% were familial PD patients. Ten patients were heterozygous for five different missense mutations (3.29%) of whom six carried the same mutation p.R1441C (1.97%). All six p.R1441C carriers were familial PD patients explaining 10.7% of familial PD in the ...
SIAXI: Efficacy and safety of Xeomin (incobotulinumtoxinA) for the treatment of sialorrhea in Parkinson’s disease (PD) and other neurological conditions: Results of a Phase III, placebo-controlled, randomized, double-blind study Vrije Universiteit Brussel
Plastic changes at corticostriatal synapses predict improved motor function in a partial lesion model of Parkinson's disease Vrije Universiteit Brussel
In Parkinson's disease, striatal dopamine depletion leads to plastic changes at excitatory corticostriatal and thalamostriatal synapses. The functional consequences of these responses on the expression of behavioral deficits are incompletely understood. In addition, most of the information on striatal synaptic plasticity has been obtained in models with severe striatal dopamine depletion, and less is known regarding changes during early ...
Place of death of people living with Parkinson's disease Vrije Universiteit Brussel Ghent University
BACKGROUND: Most people prefer to receive end-of-life care in familiar surroundings rather than in hospital. This study examines variation in place of death for people dying from Parkinson's disease (PD) across 11 European and non-European countries.
METHODS: Using death certificate data of 2008 for Belgium, France, Italy, Hungary, Czech Republic, New Zealand, USA, Canada, Mexico, South Korea and Spain for all deaths with PD as an ...