Activation of Toll-like receptor signaling impairs nasal epithelial integrity in chronic rhinosinusitis KU Leuven
The nasal and sinus tissue are lined with epithelial cells that are specialized in preventing the entry of pathogens by the formation of a physical barrier. Upon contact with the sinonasal mucosa, pathogens release factors that interact with receptors expressed on epithelial cells. Patient with chronic rhinosinusitis are often colonized by different pathogens such as Staphylococcus aureus, resulting in chronic inflammation of the sinonasal ...