Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome KU Leuven
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in tlr9 knockout mice KU Leuven Ghent University
Altered lipid composition of surfactant and lung tissue in murine experimental malaria-associated acute respiratory distress syndrome KU Leuven
Improved methods for haemozoin quantification in tissues yield organ- and parasite-specific information in malariainfected mice KU Leuven
Adrenal hormones mediate disease tolerance in malaria Institute of Tropical Medicine KU Leuven Ghent University Flanders Institute for Biotechnology
Malaria reduces host fitness and survival by pathogen-mediated damage and inflammation. Disease tolerance mechanisms counter these negative effects without decreasing pathogen load. Here, we demonstrate that in four different mouse models of malaria, adrenal hormones confer disease tolerance and protect against early death, independently of parasitemia. Surprisingly, adrenalectomy differentially affects malaria-induced inflammation by ...