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A multinational observational study exploring adherence with the kidney disease : improving global outcomes recommendations for prevention of acute kidney injury after cardiac surgery Ghent University

Mira Küllmar, Raphael Weiß, Marlies Ostermann, Sara Campos, Neus Grau Novellas, Gary Thomson, Michael Haffner, Christian Arndt, Hinnerk Wulf, Marc Irqsusi, et al.
BACKGROUND: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend a bundle of different measures for patients at increased risk of acute kidney injury (AKI). Prospective, single-center, randomized controlled trials (RCTs) have shown that management in accordance with the KDIGO recommendations was associated with a significant reduction in the incidence of postoperative AKI in high-risk patients. However, compliance with the ...

Prevention and conservative management of acute kidney injury Ghent University

Jill Vanmassenhove, Nic Veys, Wim Van Biesen
The incidence of acute kidney injury (AKI) is increasing steadily. This can be attributed to a growing prevalence of risk factors for AKI, such as aging, diabetes, underlying cardiovascular disease and the escalating application of more complex procedures. Currently, there is no treatment for established AKI, except for renal replacement therapy in case of life-threatening conditions. The focus should thus be shifted towards AKI prevention ...

Statins for the prevention of contrast-induced acute kidney injury Ghent University

Jill Vanmassenhove
PURPOSE OF REVIEW: To highlight the most recently published meta-analyses on the role of statins in the prevention of contrast-induced acute kidney injury (CI-AKI) and to formulate recommendations for clinical practice.RECENT FINDINGS: Nine meta-analyses were published on this topic from January 2015 to April 2016. Significant clinical heterogeneity between studies, regarding study population, treatment protocol, concomitant preventive ...

The prevention of acute kidney injury an in-depth narrative review Ghent University

Wim Van Biesen, Eric Hoste, Raymond Vanholder
The second part of this in-depth clinical review focuses on drugs used in the prevention of AKI in the patient at risk and/or in the management of the patient with incipient AKI. Among the drugs used to maintain a normal renal perfusion pressure, norepinephrine and vasopressin are most commonly used in hypotensive critically ill patients. The most recent RCT did not find a difference between low-dose vasopressin plus norepinephrine and ...

Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 Vrije Universiteit Brussel KU Leuven Ghent University

M. Joannidis, W. Druml, Lui G Forni, A.b.j. Groeneveld, Patrick Honoré, E. Hoste, Marlies Ostermann, H.m. Oudemans-Van Straaten, M.r.c. Schetz

BACKGROUND: Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity.

OBJECTIVES: To determine and update previous recommendations for the prevention of AKI, specifically the role of fluids, diuretics, inotropes, vasopressors/vasodilators, hormonal and nutritional interventions, sedatives, statins, remote ischaemic preconditioning and care bundles.

METHOD: A systematic search ...

Prevention of acute kidney injury and protection of renal function in the intensive care unit. Expert opinion of the Working Group for Nephrology, ESICM KU Leuven

Miet Schetz
BACKGROUND: Acute renal failure on the intensive care unit is associated with significant mortality and morbidity. OBJECTIVES: To determine recommendations for the prevention of acute kidney injury (AKI), focusing on the role of potential preventative maneuvers including volume expansion, diuretics, use of inotropes, vasopressors/vasodilators, hormonal interventions, nutrition, and extracorporeal techniques. METHOD: A systematic search of the ...