Projects
Assessment of synaptic density and mHTT aggregates in post-mortem human brain tissue of patients with Huntington's Disease. University of Antwerp
Local field potential recordings in deep brain stimulation patients KU Leuven
Deep brain stimulation (DBS) is an invasive neuromodulation method in which stimulating electrodes are chronically implanted in the brain to deliver a continuous train of electrical pulses. DBS is now routinely used to treat a range of neurological disorders such as Parkinson’s disease and essential tremor and is beginning to be used to treat some psychiatric disorders such as obsessive compulsive disorder and major depression. DBS is ...
Development of decision support systems to manage QT-prolongation in clinical practice. KU Leuven
The risk of QTc-prolongation has become an important issue in drug safety. In rare cases it can lead to serious adverse events like Torsade de Pointes and sudden cardiac death. In the last decades, several drugs have been removed from the market (e.g. cisapride) or restricted in use (e.g. domperidone, (es)citalopram) because of this risk. At the moment, more than 170 drugs are linked with this risk of QTc-prolongation, as defined in the ...
Improving treatment strategies for different depressive disorders by discovery of novel drug target candidates and discriminatory diagnostic biomarkers. University of Antwerp
Psych-STRATA - A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness KU Leuven
A key problem in Mental Health is that up to one third of patients suffering from major mental disorders develop resistance against drug therapy. However, patients showing early signs of treatment resistance (TR) do not receive adequate early intensive pharmacological treatment but instead they undergo a stepwise trial-and-error treatment approach. This situation originates from three major knowledge and translation gaps: i.) we lack ...
Transitional Models in Suicidal Thoughts and Behaviors: Multivariate Longitudinal Designs KU Leuven
The proposed PhD study is part of an international collaboration between Stellenbosch University (SUN) and the Katholieke Universiteit Leuven (KU Leuven, Belgium) (Public Health Psychiatry Universitair Psychiatrisch Centrum KULeuven). It is a funded joint PhD programme (Global joint-PhD Scholarship Programme) between SUN and KU Leuven and involves a joint PhD registration at SUN and KU Leuven. Furthermore, the proposed PhD study will comply ...