Promoter DNA methylation regulates progranulin expression and is altered in FTLD Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of sporadic FTLD is unclear.
RESULTS: We analyzed whether DNA methylation in the GRN core promoter restricts GRN expression and, thus, might ...