Projects
Investigation of the in vivo role of the EMT-inducing transcription factors and ZEB2 ZEB1 in the development and progression of melanoma and non-melanoma skin cancers Ghent University
Skin cancer is still one of the most common cancers worldwide and becomes life-threatening
upon malignant conversion to metastasis, especially in the case of melanoma. The induction
of metastasis involves the loss of cell-cell adhesion and the gain of migratory properties and is
often accompanied by Epithelial to Mesenchymal Transition (EMT). In this project we want
to investigate the role of the EMT transcription ...
Text Theatricality. An integrated approach based on rhetorical narratology and performance analysis Ghent University
The present proposal takes its cue from the increasing trend to adapt novels to the theatrical
stage and from other innovative performance practices (reading performances, installations,
social immersion projects). The project aims to study the intersection between narrative and
drama both from a theoretical point of view and in contemporary performance practices.
Selected case studies from 20th and 21st century German ...
The IceTop cosmic ray detector: study of the energy spectrum around the knee, andveto for IceCube Ghent University
The earth is constantly bombarded by charged particles from the cosmos. These cosmic
rays have energies which can be as high as 100 million times higher than those produced
in the LHC accelerator. Although they were rst discovered 100 years ago, the details of
the energy spectrum and of the composition of the cosmic rays are still not well known. In
this project we want to determine the energy spectrum, and the ...
Prediction of N2O emission from tropical forest: a modelar biosphere simulation environment (MobiLe) approach Ghent University
With regards to global climate change soils are of significant importance as sources for atmospheric trace gases such as nitrous oxide (N2O). Tropical forest soils account for 18% of global N2O emission. Therefore, this project aims to assess the effect of spatial resolution of a detailed biogeochemical model driving variables on the quantity and quality of N2O emission simulations from a tropical forest (Nyungwe) in southwest of Rwanda.
Reconstruction of dynamic initiation and progression gene expression regulatorynetworks in neuroblastoma Ghent University
Neuroblastoma (NB) is a lethal tumor of childhood for which therapy has improved little over the past decades and which is assumed to benefit from insights into perturbed signaling pathways. Recently, new genetic components in the oncogenic signaling in NB cells have been discovered. Despite these advances, details of down stream signaling and the relationship between these pathways remain elusive. Such knowledge is however crucial for ...
Microenvironmental regulation of cancer progression Ghent University
Prolonged dysregulated inflammatory conditions favor not only carcinogenesis but also
local infiltration and metastasis of malignantly modified cells and counteract the
development of efficient antitumor immunity. Epithelial Mesenchymal Transition (EMT)
now takes centre stage as the convergence point between inflammation and the
progression of degenerative fibrotic diseases and cancer. EMT is a crucial process during ...
network modeling of ecosystem services Ghent University
Ecosystem services are the goods and services an ecosystem and which have an impact on the welfare / well-being of society. The concept of ecosystem services allows us to approach the different environmental problematics from a more integrated vision development. Ecosystems can have same impact on water / management as protect against flooding and denitrification, climate change through carbon storage, air quality, recreation. So the integral ...
The interactions between the brain and MMP8 & MMP3 in systemic inflammation. KU Leuven
Transmission fo the hepatitis C virus: from understanding the mechanisms to clinical applications Ghent University
Our team created a small animal model in which wild-type hepatitis
C virus (HCV) infections can be studied. Using this mouse model as well as
different in vitro models we will study in detail the diverse mechanisms of HCV
transmission. In addition we will evaluate novel strategies to prevent HCV
infection.