Microdomain modulation of ryanodine receptors in post-myocardial infarction remodeling of cardiac myocytes. KU Leuven
After a myocardial infarction the burden on the surviving heart tissue increases. In response, the cells grow bigger and adapt to maintain the pump function of the heart. Unfortunately, these adaptive changes are limited and the heart now has a reduced work capacity. The changes also carry unwanted consequences as the heart becomes more vulnerable to rhythm disorders. In the current project we examine the changes in one of the key proteins ...