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Single-cell PCR analysis of murine embryonic stem cells cultured on different substrates highlights heterogeneous expression of stem cell markers KU Leuven
BACKGROUND INFORMATION: In the last few years, recent evidence has revealed that inside an apparently homogeneous cell population there indeed appears to be heterogeneity. This is particularly true for embryonic stem (ES) cells where markers of pluripotency are dynamically expressed within the single cells. In this work, we have designed and tested a new set of primers for multiplex PCR detection of pluripotency markers expression, and have ...
"Where will I belong more?": The role of belonging comparisons between STEM fields in high school girls' STEM interest KU Leuven
UNLABELLED: In trying to understand women's underrepresentation in STEM (Science, Technology, Engineering, Mathematics), most existing research focuses on one STEM-field or collapses across all STEM-fields. However, these fields differ vastly in female representation: women tend to be most strongly underrepresented in technological and computer science university majors and to a lesser extent in mathematics and chemistry, while they are less ...
Stem cells in the pituitary gland and candidate cancer stem cells in pituitary tumors KU Leuven
It has repeatedly been postulated that the pituitary gland contains stem cells, putatively involved in the generation of new hormonal cells during homeostatic turnover as well as during plastic remodelling in response to changing endocrine needs of the body. In previous studies, our group clearly designated a candidate stem cell population in the anterior pituitary (AP) lobe of the adult mouse using the side population (SP) approach. In the ...
Embryonic Stem Cell-Derived Mesenchymal Stem Cells (MSCs) Have a Superior Neuroprotective Capacity Over Fetal MSCs in the Hypoxic-Ischemic Mouse Brain KU Leuven
Human mesenchymal stem cells (MSCs) have huge potential for regenerative medicine. In particular, the use of pluripotent stem cell-derived mesenchymal stem cells (PSC-MSCs) overcomes the hurdle of replicative senescence associated with the in vitro expansion of primary cells and has increased therapeutic benefits in comparison to the use of various adult sources of MSCs in a wide range of animal disease models. On the other hand, fetal MSCs ...
Spermatogonial stem cells. An update on spermatogonial stem cell banking and transplantation Vrije Universiteit Brussel
Like every other adult stem cell in the human body, spermatogonial stem cells (SSCs) have the capacity to either renew themselves or to start differentiation, i.e. spermatogenesis. Due to these properties, several options for preservation and re-establishment of the spermatogenic process exist.
Prevention of sterility has become an important issue in reproductive medicine. For adult men, sterility after cancer treatment can be ...
Prevention of sterility has become an important issue in reproductive medicine. For adult men, sterility after cancer treatment can be ...
Establishing a model organism for stem cell research: the stem cell system of the rhabditophoran flatworm Macrostomum lignano during embryonic development, post-embryonic development, regeneration and ageing Ghent University
The model system approach is an extraordinary powerful tool to study animal development or any other biological process. The challenge is to determine the best criteria for choosing new model organisms, given limited resources. Examples of such criteria are that (1) the selected animal should be one in which the trait of interest (e.g. stem cells, regeneration) is patently manifested, (2) the selected animal should be relatively easy to ...
Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells Flanders Institute for Biotechnology KU Leuven Hasselt University
Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function KU Leuven
© 2017, Mary Ann Liebert, Inc. During ontogeny, fetal liver (FL) acts as a major site for hematopoietic stem cell (HSC) maturation and expansion, whereas HSCs in the adult bone marrow (ABM) are largely quiescent. HSCs in the FL possess faster repopulation capacity as compared with ABM HSCs. However, the molecular mechanism regulating the greater self-renewal potential of FL HSCs has not yet extensively been assessed. Recently, we published RNA ...
Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise KU Leuven
Despite advances in cardiovascular biology and medical therapy, heart disorders are the leading cause of death worldwide. Cell-based regenerative therapies become a promising treatment for patients affected by heart failure, but also underline the need for reproducible results in preclinical and clinical studies for safety and efficacy. Enthusiasm has been tempered by poor engraftment, survival and differentiation of the injected adult stem ...