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Sulfadoxine-pyrimethamine resistance and intermittent preventive treatment during pregnancy: a retrospective analysis of birth weight data in the Democratic Republic of Congo (DRC) Institute of Tropical Medicine

JL Likwela, U D'Alessandro, BL Lokwa, S Meuris, MW Dramaix
Objective
To assess the effect of intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) on birth weight in sites with varying degrees of drug resistance.
Methods
Birth weight data from three regions in Democratic Republic of Congo with varying degrees of sulfadoxine-pyrimethamine (SP) resistance (1.6% in Mikalayi, 21.7% in Kisangani and 60.6% in Rutshuru) were analysed retrospectively by means of a logistic ...

Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulphadoxine-pyrimethamine + artesunate in Huambo and Bié provinces, central Angola Institute of Tropical Medicine

JP Guthmann, J Ampuero, F Fortes, C Van Overmeir, V Gaboulaud, S Tobback, J Dunand, S Nilton, P Gillet, J Franco, et al.
We studied three antimalarial treatments in Caala and Kuito, Angola, in 2002 and 2003. We tested chloroquine (CQ), amodiaquine (AQ) and sulfadoxine-pyrimethamine (SP) in Caala, and AQ, SP and the combinations AQ + artesunate (AQ + AS) and SP + artesunate (SP + AS) in Kuito. A total of 619 children (240 in Caala, 379 in Kuito) with uncomplicated Plasmodium falciparum malaria were followed-up for 28 days, with PCR genotyping to distinguish ...

Community-based malaria screening and treatment for pregnant women receiving standard intermittent preventive treatment with sulfadoxine-pyrimethamine Vrije Universiteit Brussel

Susana Scott, Umberto d'Alessandro, Lindsay Kendall, John Bradley, Kalifa Bojang, Simon Correa, Fanta Njie, Halidou Tinto, Maminata Traore-Coulibaly, Hamtandi Magloire Natama, et al.

Background. We investigated whether adding community scheduled malaria screening and treatment (CSST) with artemether- lumefantrine by community health workers (CHWs) to standard intermittent preventive treatment in pregnancy with sulfadoxine- pyrimethamine (IPTp-SP) would improve maternal and infant health. Methods. In this 2-arm cluster-randomized, controlled trial, villages in Burkina Faso, The Gambia, and Benin were randomized to receive ...

Evaluation of the usefulness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine in a context with increased resistance of Plasmodium falciparum in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo Ghent University

Nadine Kalenda Kayiba, Doudou Malekita Yobi, Vanessa Rodanis Kouoneyou Tchakounang, Dieudonné Makaba Mvumbi, Pius Zakayi Kabututu, Brecht Devleesschauwer, Erick Sompwe Mukomena, Patrick De Mol, Marie-Pierre Hayette, Georges Lelo Mvumbi, et al.
Background: Increasing resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) threatens its usefulness for intermittent preventive treatment in pregnancy (IPTp-SP). The prophylactic effects of IPTp-SP on maternal malaria and adverse pregnancy outcomes were evaluated in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo (DRC). Methods: Laboring women (n = 844) and respective newborns were investigated. Blood samples ...

The influence of pregnancy on the pharmacokinetic properties of artemisinin combination therapy (ACT) Institute of Tropical Medicine

Renee J. Burger, Benjamin Jelle Visser, Martin P. Grobusch, Michele van Vugt

Background: Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based combination therapy (ACT). However, small sample sizes make it difficult to draw strong conclusions based on individual pharmacokinetic studies. The aim of this review is to summarize the evidence of the influence of pregnancy on the pharmacokinetic properties of different ...