Publications

Chosen filters:
Chosen filters:

1 - 10 of 22421 results

Sorteren op
Search term:

Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition : an analysis of real-time collected data Ghent University

Joris Vermassen, Johan Decruyenaere, Liesbet De Bus, Pieter Depuydt, Kirsten Colpaert
Background Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that only comply with the Sepsis-2 definition. We conducted a retrospective cohort study on the ICU of a Belgian tertiary care facility to seek out differences between these two patient groups and to identify variables associated with no longer satisfying the latest definition of septic shock. ...

Sepsis and septic shock: pathophysiological and cardiovascular background as basis for therapy. Vrije Universiteit Brussel

I. De Kock, C. Van Daele, Jan Poelaert
Introduction Sepsis and septic shock are common causes for admission to intensive care units. The morbidity and mortality remain unacceptably high despite the advanced treatments.
Objectives To review the most commonly reported underlying mechanisms of sepsis and septic shock, besides discussion of sepsis-induced cardiovascular dysfunction.

Therapeutic strategies for sepsis-induced myocardial depression are briefly discussed. ...

Sepsis and septic shock: pathophysiological and cardiovascular background as basis for therapy Ghent University KU Leuven

Caroline Van daele, Jan Poelaert
Introduction: Sepsis and septic shock are common causes for admission to intensive care units. The morbidity and mortality remain unacceptably high despite the advanced treatments. Objectives: To review the most commonly reported underlying mechanisms of sepsis and septic shock, besides discussion of sepsis-induced cardiovascular dysfunction. Therapeutic strategies for sepsis-induced myocardial depression are briefly discussed. Data synthesis: ...

Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments Vrije Universiteit Brussel University of Antwerp KU Leuven

Stefanie Vandervelden, Lina Wauters, Jan Breuls, Steffen Fieuws, Philippe Vanhove, Ives Hubloue, Magali Bartiaux, Jacques Creteur, François Stifkens, Koen Monsieurs, et al.

BACKGROUND: Sepsis is a potentially life-threatening condition characterized by a deregulated body's response to infection causing injury to its own tissues and organs. Sepsis is the primary cause of death from infection. If not recognized and treated timely, it can evolve within minutes/hours to septic shock. Sepsis is associated with an acute deficiency of Vitamin C. Despite the proof-of-concept of the benefit of administering Vitamin C in ...

Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock Vrije Universiteit Brussel

Fabio Silvio Taccone, Pierre-François Laterre, Thierry Dugernier, Herbert Spapen, Isabelle K Delattre, Xavier Wittebole, Daniel De Backer, Brice Layeux, Pierre E Wallemacq, Jean-louis Vincent, et al.

Introduction: Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum β-lactam concentrations when standard dosages are administered. Previous studies on β-lactam PK have generally excluded the most severely ill patients, or were conducted during the steady-state period of treatment. The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem ...

Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock Vrije Universiteit Brussel

Fabio Silvio Taccone, Pierre-François Laterre, Herbert Spapen, Thierry Dugernier, Isabelle K Delattre, Brice Layeux, Daniel De Backer, Xavier Wittebole, Pierre E Wallemacq, Jean-louis Vincent, et al.

Introduction: It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased volume of distribution (Vd), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients.Methods: This was an open, prospective, multicenter study in four Belgian intensive care units (ICUs). ...

Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies Ghent University

Dominique Vandijck, Dominique Benoit, Pieter Depuydt, Fritz Offner, Stijn Blot, Anna K Van Tilborgh, JOKE NOLLET, EVA STEEL, Lucien Noens, Johan Decruyenaere, et al.
Objective: To compare the characteristics and outcome of patients with hematological malignancies referred to the ICU with severe sepsis and septic shock who had or had not received recent intravenous chemotherapy, defined as within 3 weeks prior to ICU admission. Design and setting: Retrospective observational cohort study on prospectively collected data in a medical ICU of a university hospital. Patients: 186 ICU patients with hematological ...

An update on membranes and cartridges for extracorporeal blood purification in sepsis and septic shock Vrije Universiteit Brussel

Patrick Honoré, David De Bels, Herbert Spapen

RECENT FINDINGS: Despite positive signals from experimental, cases and small clinical studies, blood purification showed no distinct morbidity and mortality benefit in large clinical trials.

SUMMARY: None of the discussed specific membranes or cartridges can currently be recommended as sole adjunctive treatment in sepsis and septic shock. Any available technique should be timely initiated and adapted to the patient's status. Sickest ...