Combining metabolomics and genomics technologies to study platinum-based therapeutic failure in high grade ovarian cancers: from predictive signature(s) to novel therapeutic strategies. KU Leuven
Surgery followed by platinum-based chemotherapy is the standard of care treatment for patients with advanced high-grade serous ovarian cancer. Platinum regimens, however, are characterized by the progressive development of resistance and tumor relapses that ultimately lead to therapeutic failure. Platinum-resistance is a major clinical and socio-economic problem in the treatment of ovarian cancer and the development of new strategies to ...