Exploring the role of Aβ, Tau and Tau modulators in inducing neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven
Neuronal cell loss is an ultimate hallmark of the many neurodegenerative diseases including Alzheimer’s disease (AD). However, neuronal cell death phenotype is seldom investigated. In AD, the relationship between Amyloid β (Aβ) peptide, Tau, and neuronal death is a central problem. Nevertheless, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what ...