Publications
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Prognostic factors for changes in the timed 4-stair climb in patients with Duchenne muscular dystrophy, and implications for measuring drug efficacy: A multi-institutional collaboration KU Leuven
The timed 4-stair climb (4SC) assessment has been used to measure function in Duchenne muscular dystrophy (DMD) practice and research. We sought to identify prognostic factors for changes in 4SC, assess their consistency across data sources, and the extent to which prognostic scores could be useful in DMD clinical trial design and analysis. Data from patients with DMD in the placebo arm of a phase 3 trial (Tadalafil DMD trial) and two real-world ...
Evolution of RAS testing over time: factors influencing mutation rates in metastatic colorectal cancer patients KU Leuven
Aim: Correct identification of RAS gene variants is key for targeted treatment decisions in patients with metastatic colorectal cancer. Published RAS mutation rates differ and could be influenced by several factors including testing methods. This study aimed to describe the performance of laboratories to correctly identify RAS variants over time and to understand how RAS testing has evolved in Europe. Materials & methods: Misclassification ...
Validation of standard times and influencing factors during the development of the Workload Indicator for Nursing Ghent University
Groundwater inflow in rivers as a controlling factor to surface water nitrate concentrations and impact of groundwater age distribution on response times for remediation strategies Ghent University
Diffuse groundwater contamination by intense fertilizer use is a widespread problem in most of the agricultural regions in West-Europe and in many other countries worldwide. As a result elevated nitrate concentrations in groundwater are found, and as groundwater is the source of baseflow into rivers and streams, also surface waters show increased nitrate levels. Flanders in the north of Belgium is no exception and despite restrictions on the ...
Hypertension : time for doctors to switch the driver's seat? Ghent University
A generalized linear factor model approach to the hierarchical framework for responses and response times KU Leuven
We show how the hierarchical model for responses and response times as developed by van der Linden (2007), Fox, Klein Entink, and van der Linden (2007), Klein Entink, Fox, and van der Linden (2009), and Glas and van der Linden (2010) can be simplified to a generalized linear factor model with only the mild restriction that there is no hierarchical model at the item side. This result is valuable as it enables all well-developed modelling tools ...