Protein aggregation in cancer development: novel heat shock inducing compounds to reduce tumor growth. KU Leuven
Targeting protein aggregation during cancer development
1.1 Mutant p53 protein can exert gain-of-function activity by protein aggregation
Cancer remains one of the leading causes of morbidity and mortality worldwide, and understanding the underlying molecular mechanisms of the disease still forms a major challenge1-4. The p53 tumor suppressor protein, a master regulator of cell cycle arrest and apoptosis, is a cardinal player in ...